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In big systematic reviews of studies that include these and higher doses, daily intake above 200mg has often shown a decrease in efficacy that researchers call a U-shaped curve.24 That means, for the average person, taking more than 200mg could potentially work against their goals

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The SURMOUNT program, the SURPASS program for diabetes, the SUMMIT cardiovascular trial, and the phase 2 type 1 diabetes trial collectively represent one of the most extensive evidence bases for any weight loss intervention in history

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