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The paper reports the absence of the positive effect under twice-daily dosing rather than a measured decrement, and no head-to-head statistical comparison of the two schedules is given but even read at its most conservative, that is not how a dose-dependent hypnotic behaves

Wasted money and lost momentum Beyond the biological risks, there is a practical cost

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The human microbiome, especially the gut microbiota, comprises numerous symbiotic bacterial species (e.g., Lactobacillus , Bacillus , Clostridium , Enterococcus , and Ruminococcus ) that collectively represent approximately 90% of the gut flora (Rinninella et al., 2019