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Common Causes of Peptide Impurities Solid-phase peptide synthesis errors Incomplete deprotection reactions Amino acid racemization Aggregation and degradation Regulatory guidelines usually require identification of impurities present at 0.10% relative abundance in peptide drug substances

It may cause gastrointestinal symptoms, such as gas, bloating, diarrhea, and abdominal discomfort, especially when consumed in large doses