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These modifications allow Ozempic (semaglutide) to hang around much longer bound to a protein called albumin, and resist being broken down by DPPIV enzymes whose job it is to deactivate GLP-1

Further, the inclusion of HIF while inhibiting GPX4 mitigates GPX4-mediated ferroptosis

Advantages include long shelf life when stored properly (below -20C)

It works by activating melanocortin receptors throughout the body, including pathways involved in melanin production, desire and arousal signaling, appetite and satiety, inflammatory balance, and broader mind-body communication

38 (12), 592602 (2013) Hunter, R., Caira, M., Stellenboom, N.: Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent