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As we see a higher amount of burst release and lower proportion of drug retained over prolonged timeframes for semaglutide, we hypothesized that there is likely a substantial fraction of free cargo (i.e., not adhered to the PNP hydrogel matrix) that undergoes fast, diffusion-based release

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Liraglutide treatment, both alone and in combination with CPAP, led to a significant weight reduction of 6.2 and 3.7 kgs, respectively, which was not observed with CPAP alone