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134 Aged mice show a decrease in the reconstitution capability of their hematopoietic stem cells (HSCs), correlating with an increase in DNA damage 135,136 and with an increase in the levels of senescence effectors, such as p16INK4a

(2025) Proc Natl Acad Sci U S A 122 : e2407574122-e2407574122 PubMed: 40168114 Search on PubMed DOI: Primary Citation Related Structures: 9EBN, 9EBO, 9EBQ PubMed Abstract: Signal duration and subcellular location are emerging as important facets of G protein-coupled receptor (GPCR) function