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Classic symptoms include: Sudden, intense pain in the right upper abdomen or center of the abdomen, often radiating to the right shoulder or back Pain episodes (biliary colic) lasting 30 minutes to several hours, typically occurring after meals Nausea and vomiting accompanying abdominal pain Fever and chills, which may indicate cholecystitis or infection Jaundice (yellowing of skin or eyes), suggesting bile duct obstruction Clay-colored stools or dark urine Persistent indigestion or bloating It is important to note that many gallstones remain asymptomatic and are discovered incidentally on imaging performed for other reasons

Many of the histaminergic neurons lay in close proximity to the third ventricle or are located on the ventral surface of the brain, suggesting, like other hypothalamic neurons, a potential for the detection of circulating hormones and neuropeptides ( Histamine receptor signaling Histamine exerts its pleiotropic effects by binding to four subtypes of histamine receptors (HR), three of which are located within the brain (H1R, H2R, and H3R) ( Identified in 1966, the H1R subclass of histamine receptors (gene symbol: HRH1) primarily couples to Gq, resulting in the activation of the phospholipase C (PLC) signaling pathway ( Figure 2 )