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Non-selective c-Met inhibitors include crizotinib (PF-02341066), foretinib (XL-880), cabozantinib (XL-184), glesatinib (MGCD265), BMS-777607, and MK2461, which in addition to c-Met, can inhibit other tyrosine kinases, such as ALK, RON, VEGFR2, KIT, TIE2, PDGFR, VEGFR1, VEGFR3, RET, and FLT-3 [163,164,165], through binding to the ATP binding site on tyrosine kinases

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A member of S-transferase superfamily, GSTM1 has been reported to be associated with anti-RO antibodies suggesting that the dysfunction of this gene may contribute to the anti-Ro autoantibody response or to photosensitivity [66,67]