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At the indicated time points, 1 L of reaction was withdrawn, diluted 6-fold in Replication Stop Dye (3.6% SDS, 18 mM EDTA, 90 mM Tris-HCl pH 8, 90 mg/mL Ficoll, and 3.6 mg/mL Bromophenol Blue), incubated with 20 mg proteinase K at 21C for 16 h, and then resolved by 0.8% agarose gel electrophoresis

In clinical MRSA strains, the MIC decreased from 8 g/ml when using regular teicoplanin to 0.125 g/ml when using teicoplanin-aptamer-PLGA nanoparticles [210]

References: [2] [3] [6] [7] [8] [11] [12] [13] [14] [16] [17] [18] [20] [21] [23] [24]