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Total projected weight loss at 48 weeks is approximately 20 to 26% of starting body weight for most individuals

Example conceptual model: While this approach has not yet been validated in large clinical trials, it reflects the idea that metabolic response may scale with body mass and lean tissue metabolism

Zhihong Y, Chen W, Qianqian Z, Lidan S, Qiang Z, Jing H, et al

"I lost 26 pounds on Ozempic but was terrified I was losing muscle

BBR modulates BA metabolism primarily through alterations in gut microbiota composition, particularly enhancing the abundance of bacteria capable of converting primary to secondary BAs [95]