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In respect to their cardiovascular effects among patients with T2DM, both GLP-1RAs and SGLT2is have been shown to reduce the risk of MACE (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke), with GLP-1RAs reducing the risk of non-fatal stroke to a greater extent [3, 6]

Considering the adherence of this patient, we chose dulaglutide, a once-weekly GLP-1 receptor agonist, instead of the once-daily GLP-1 receptor agonists

30 PKA then promotes the synthesis of insulin peptide precursor in beta-pancreatic cells and inhibits the release of glucagon by alpha pancreatic cells

GIP receptor activation The GIP component enhances the metabolic effects of GLP-1 activation and contributes to improved glucose handling