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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

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Core Principles IV NAD: high dose, infrequent, best for initial loading and occasional maintenance SQ NAD: moderate dose, frequent, great for bridging between IV sessions Oral NAD: Daily dose, steady baseline support Pre-Week 1 Before you even receive your first IV, we recommend you start with NR or NMN oral pills at around 250mg to prime your system before any parenteral dosing