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confirmed and extended the observation, where GLP-1 significantly increased myocardial glucose uptake under basal conditions in lean humans, but this effect was impaired in T2D [47]

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This study confirmed the findings of an earlier pooled analysis of 25 randomised clinical trials totalizingsimilarly to the TECOS trialalmost 15,000 patients, which did not indicate that treatment with sitagliptin increases cardiovascular risk in patients with T2DM [76]

Webster CD, Muzinic LA, Thompson KR