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Crit Rev Immunol 14:293 Apostolopoulos V, Bojarska J, Chai T-T, Feehan J, Kaczmarek K, Matsoukas JM, Paredes Lopez O, Saviano M, Skwarczynski M et al (2022a) New advances in short peptides: looking forward, vol 27

[16] [17] These reductions occurred alongside substantial weight loss and appeared dose-dependent, with higher tirzepatide doses producing greater blood pressure improvements

Most providers recommend a four-to-eight week trial period

Human data is still very limited, including small pilot work such as the knee pain survey of 16 patients, plus a few other early studies and reviews calling out the lack of large, rigorous trials