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Several nutritional deficiencies have been identified in patients with fatigue and widespread tenderness, in whom supplementation with various nutrients (B-vitamins, magnesium, and malate) has shown positive results.48-50 Magnesium is the most common co-factor in enzymatic reactions in the body and, along with the B-vitamins, is of particular importance in the aerobic metabolic reactions of the Krebs cycle

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COX-2 inhibitors may also impair the removal of excess cholesterol from blood vessel walls, a process known as reverse cholesterol transport (Reiss 2009)

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