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In addition, we correlated the SF conversion rate to trends in fecal microbiota, collected prior to the GR intervention, which might predict which participants would respond to GR alone based on their existing microbial community

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Building upon this initial VP64 fusion, the combinatory fusion of VP64, p65, and Rta (VPR) to the C-terminus of dCas9 produces significantly higher transcriptional activation, with an effect size ranging from 22-fold to 320-fold greater than VP64 alone [68]

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