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Upon binding to the erythropoietin receptor (EpoR, located on the surface of erythroid progenitor cells), EPO activates Jak2/STAT5, Ras/Raf/MEK/ERK and PI3K/Akt signaling pathways [41, 42] with consequent downstream recruitment of GATA-1 transcription factor [43], a master regulator of erythropoiesis critically affecting all aspects of cell survival and proliferation