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Expert panel report

The GCGR component is specifically hypothesised to contribute via cyclic AMP-mediated beta-oxidation pathways in hepatocytes, though this mechanistic attribution requires further controlled validation [VERIFY]

Wegovy 7.2 mg, approved in January 2026, also produces it at high rates (22.9% versus 6.0% at 2.4 mg)

doi: 10.1128/MCB.01149-09 141 SunJLongchampsRJPiggottDACastellaniCASumpterJABrownTTet al