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Additionally, increased ChaC2 expression targets the Cadherin 1 gene (encoding E-cadherin) mutation, resulting in E-cadherin loss, increased epithelial-mesenchymal transformation and lymph node metastasis, ultimately contributing to the low differentiation of breast cancer (50)

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These findings support 16 weeks as the minimum required period to attain peak improvement in rolling scars and initiate a response in ice pick scars