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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) (40)

Despite numerous studies, the causes of the obesity epidemic are still not fully understood, and traditional calorie-restricted diets still lack long-term effects (133)

These symptoms, while uncomfortable, are part of the normal adaptation process and are consistent with the clinical trial experience

In this study, Bbs5 / mice showed impaired nest-building behavior (Figure 1F), indicative of potential learning and/or motor deficits

The triple mechanism offers additional pathways