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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

Reduction of Inflammation Chronic inflammation is a major hurdle in recovery

[97] observed a potential association between semaglutide and NAION, with incidence rates of 4.28 and 7.64 per 1,000 person-years in patients with T2DM and those who were overweight or obese, respectively, over 36 months

These outcomes are of significant importance in paving the road towards the incorporation of NSS as a candidate strategy against MSG-induced abnormalities, and opening interesting possibilities for studying its effectiveness in fighting other side effects of MSG

Clear explanation of risks : Any doctor proposing an off-label procedure has an ethical obligation to discuss all known risks, including those described in the section above