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When it comes to the impact of GLP-1RAs on lipid metabolism of differentiated adipocytes, controlling expression of fatty acid synthase (FASN) and adipose triglyceride lipase (ATGL) enzymes is a significant issue [133]

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The study, published Monday in the journal Nature Medicine, is one of the first big-picture looks at the benefits and risks of these new drugs, which rapidly made an impact on health care, insurance coverage, the grocery industry, and even the economy of an entire country (Denmark, where Novo Nordisk, the maker of Ozempic and Wegovy is based.) These drugs have also been given partial credit for a recent dip in obesity rates in the US, which dropped in 2023 for the first time in over a decade

The FDA resolved the semaglutide shortage in late 2024 and the tirzepatide shortage in early 2025, which narrowed the compounding lane without eliminating legitimate, patient-specific compounding