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Also, some research suggests that Rosmarinus officinalis leaf extracts and some of their metabolites like indirubin (IND), prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 6-formylindolo[3,2-b] carbazole (FICZ) and pityriazepin (PZ) inhibits the AhR activation (Aryl hydrocarbon receptor) in human keratinocytes
Thus, like in other ciliopathy models (7, 15, 16), ablation of Bbs5 led to aberrant pancreatic morphology, defective insulin signaling, and impaired glucose homeostasis