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Since the different agonists/compounds, all of which stimulate Gs recruitment to the GIP receptor, have distinct pharmacology, they may affect interaction of the various effector molecules with the GIP receptor differently (39, 42) ( Figure 2 )

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In a study of 2,000 participants, those who combined semaglutide with diet and exercise lost an average of 15% of their body weight after 68 weeks, with nearly one-third losing 20%

Lancet (2016) 387(10019):67990