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Class 2 lesions usually are not amenable to surgical repair and are treated with dbridement

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For other epigenetic mechanisms, including ATP-dependent chromatin remodeling, histone de/acetylation, neuron-restrictive silencing factor (NRSF/REST)-mediated gene regulation and non-coding RNA, we refer the reader to excellent reviews (Ballas et al., 2005

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Sheu) for subtle smoothing

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Mol Neurobiol 63:75

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