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Cani & group assessed the effects of 2-week prebiotic treatment on satiety and gut hormones in a randomized, double-blind experiment including 10 healthy individuals 67

The article names constipation lasting more than three to five days despite home measures, or accompanied by severe abdominal pain, distension, or loss of appetite, as reasons for immediate provider contact, since these can signal bowel obstruction or other complications

Specifically, the macrophage population in DW has undergone significant changes

Mol Metab , 91 , 102067

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