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slow 8-week regimens brought it to 0-3.8%, near placebo, at no efficacy cost (Frias 2020): Frias Lancet 2018

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The realistic expectation is slowed degeneration, reduced pain, and improved function

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Common reconstitution volumes: 20mg vial + 2mL BAC water = 10mg/mL concentration 40mg vial + 2mL BAC water = 20mg/mL concentration 40mg vial + 3mL BAC water = 13mg/mL concentration Add diluent slowly: Insert the needle into the vial at an angle and allow the water to flow down the inside wall of the vial