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A major issue with many lead compounds is increased cardiovascular risk due to drug-induced QTc prolongation (35)

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Adults 65 and older have the highest diabetes rate of any age group, about 29%, yet their GLP-1 use drops to 9%, below the middle-aged group and below the national average

Standard Zepbound/Mounjaro Escalation Schedule The tirzepatide escalation schedule is more gradual than semaglutide, with six dose levels instead of five

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