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Common adverse effects include gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation), which typically improve over time

[230][231] GLP-1 is stored in the L-cells of the ileum and colon, and released at mealtime in response to neurohormonal signals and the presence of food in the gut

The trial results showed that after a 68-week treatment period, the oral semaglutide group achieved a significant weight reduction compared to the placebo group, with a 17.4% decrease in body weight versus 1.8% in the placebo group

Ageing and neuronal vulnerability

It cuts intake, and it pushes the liver and other tissues to burn more