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To address this limitation, multimodal biomarkers have been developed, including fluid markers such as plasma GFAP and chitinase-3-like protein 1 (YKL-40) that differentially associate with amyloid versus tau pathology, positron emission tomography (PET) tracers targeting astrocytic MAO-B that provide complementary in vivo readouts and proteomic analyses identifying novel candidates such as VCAM1 and BST2 141,142,143,144

UV radiation is considered to be the major risk factor for the development of melanoma [213, 214]

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