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The secretion of inflammatory cytokines, such as tumor necrosis factor (TNF)-a, would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions

BMI requirements were increased to greater than 40 mg/kg2 or greater than 35 mg/kg2 with one more weight-related comorbidity

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That said, more research is needed to fully understand how this works on a molecular level and how this can be applied in humans