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These three enzymes seem to be originally derived from primary Leu biosynthesis, and due to neo-functionalization show an activity toward 2-oxo (keto)-acids of Met in GSL biosynthesis
Gallbladder-related events, including cholelithiasis and cholecystitis, occur more frequently with GLP-1 therapy, likely related to rapid weight loss rather than direct drug effects
However, this study had limited duration of drug use and a lack of controls in the regression model for wet AMD risk factors, such as baseline PDR and DME status, smoking history, hemoglobin A1c, and history of dry AMD
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