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531 More accurate studies of morphology of astrocytes in aged mice in situ using intracellular injections of fluorescent dye Alexa Fluor 594 with subsequent two-photon imaging and 3D reconstruction identified a substantial reduction of astrocytic size and complexity with particular degradation of perisynaptic leaflets (Fig

& Dai, D.-Q

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These findings suggest that direct and indirect lactylation coexist rather than exclude each other, and the dominant pathway likely depends on protein expression patterns in brain cells (Hagihara et al., 2021