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In the brain this is most likely catalyzed by pyruvate carboxylase (PC) which has a higher activity than the other enzymes capable of synthesizing oxaloacetate, i.e., malic enzyme (ME) and phosphoenolpyruvate carboxykinase ( de novo synthesis of the carbon skeleton of glutamate and GABA via glutamine requires astrocytic participation [see Ref

J Phys Chem 90:11231126 Dong MM, Trenholm R, Rosario-Ortiz FL (2015) Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents

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Role of ginsenosides, the main active components of panax ginseng, in inflammatory responses and diseases