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To examine whether PDS5B colocalizes with stalled replication forks, we utilized the SIRF (in situ protein interactions with nascent DNA replication forks) assay with or without hydroxyurea (HU) treatment to induce replication stress 33

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a 10 mg vial in the same 2 mL gives 5 mg/mL

The study found that CoQ10 monotherapy did not significantly reduce symptoms compared to a placebo, highlighting that a single nutrient may not be enough to overcome deeply entrenched mitochondrial dysfunction

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