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Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin

Some data suggests that a meaningful portion of weight lost on GLP-1 medications can come from lean mass

Retatrutide is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved agents such as semaglutide or tirzepatide

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In the context of a restricted assay-format, in which implication of free LASSS can be excluded, the outcomes may provide critical insights towards understanding of an underlying LASSS-driven mechanism