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Semaglutide GLP-1 is a prescription medication that belongs to a class of medicines called GLP-1 receptor agonists

Commonly reported side effects in the Phase 2 trial included: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating Eructation (belching) The majority of participants who discontinued treatment did so due to gastrointestinal side effects, underscoring the importance of the slow titration schedule used in trials

The reality across all these products is that the skin barrier effectively blocks peptides larger than 500 Daltons from absorption, making their weight loss claims scientifically implausible

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At higher doses, patients lost an average of nearly a quarter of their body weight, exceeding outcomes typically reported with current licensed treatments such as Wegovy (~15%) or Mounjaro (~20%)