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Int J Mol Sci 20(24):6343

While timelines vary, GLP-1 medications follow a fairly predictable pattern when used consistently

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Seek urgent medical attention if you develop: Sudden unilateral (one-sided) leg swelling, which could indicate deep vein thrombosis (DVT) contact NHS 111 or seek same-day assessment Chest pain or shortness of breath with leg swelling call 999 as this could indicate a pulmonary embolism If you are considering medications for weight management, discuss your lipoedema diagnosis or suspicion openly with your GP

In selected individuals who manifest the above symptoms or disorders and who have not responded adequately to standard therapies, a trial of L-carnitine may be considered