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or A BMI between 27 and 30 and at least one weight-related comorbidity

For patients with heart failure taking beta-blockers, optimization of beta-blocker dosing should be prioritized to maintain target heart rate goals in accordance with heart failure guidelines

These effects are generally dose-dependent and tend to be most pronounced during dose escalation periods

More recently, the SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes

However, a recent study did not support this finding but rather attributed the increased risk of insulin resistance to the concomitant presence of metabolic dysfunctionassociated steatotic liver disease (MASLD) (81)