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Metabolites not only reflect the inflammatory microenvironment but also actively shape immune cell phenotypes and functions (Zheng et al., 2025

The preparation of methylguanidine, and of -dimethylguanidine by interaction of dicyanodiamide, and methylammonium and dimethylammonium chlorides respectively

This is often measured by an increase in alpha wave production in the brain, which was illustrated in a study looking at L-theanines relaxation potential after 40 minutes of administration in a dose range of 50-200mg.13 A systematic review of L-theanine specifically studied for sleep declared that a range of 50-655mg could improve sleep onset latency, total sleep time, sleep efficiency, overall sleep quality, and next-day alertness.17 Neurological health (including memory and attention) Animal studies have shown that L-theanine can cross the blood-brain barrier through both oral and intravenous administration.18 19 Once there, in addition to its calming effect, L-theanine has been shown to improve recognition and recall scores in patients with mild cognitive impairment at as little as 60mg/day.20 It was also shown to improve attention and reaction time in subjects at 200mg/day on its own or combined with 160mg of caffeine.5 21 Longevity There is limited human evidence looking at L-theanine in isolation, but animal studies have shown a small increase in average lifespan and maximum lifespan with L-theanine supplementation.22 And a cohort study looking at participants with constant tea consumption status found that tea consumption effectively slowed biological aging.23 More direct human research is needed, but these results are promising

Purpose-built for physicians New data links GLP-1 agonists for weight loss with higher risk for pancreatitis, GI events Key takeaways: GLP-1 agonists were associated with a 9.09 times increased risk for pancreatitis

A., & Kalaany, N