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Supplementation with NO donors (e.g., sodium nitroprusside) restores NO-cGMP-cGKI signaling in erythrocytes, inhibits PS externalization, and prolongs erythrocyte lifespan in CKD models (Fller et al., 2008a)

doi: 10.1016/j.ejogrb.2018.07.002

It may help reduce oxidative stress that fuels dull tone and pigmentation

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Additionally, elevated levels of the plasma amino acid homocysteine can be a functional marker of folate, vitamin B12, or vitamin B6 deficiency, as all these vitamins are required to convert homocysteine into methionine