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These are most likely when starting treatment or increasing the dose, and typically ease over time

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Clinical trials including the STEP program demonstrated that once-weekly semaglutide produced significant weight loss (up to 15% body weight reduction) compared to placebo when dosed consistently

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As stated in an article published by the Journal of Medical Internet Research in February 2025, a survey-based study was conducted on 5,591 adults in the U.S