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If knowing BBB status could potentially help us guide acute stroke care decisions, understanding the exact mechanisms behind the BBB dysregulation and the pathophysiology leading to HT is key to come up with a direct therapeutic strategy to modulate BBB

The combination of both effects is the pharmacological rationale of the stack

Metabolomics, as an important component of systems biology, was first proposed by Steven Oliver in 1998 and has since become a key method for studying the interactions between genes and the environment (Rochfort, 2005)

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