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The more important question is not simply whether it works, but: How large and durable the benefits are Which populations benefit most How the benefits compare with the risks Whether weight returns after treatment stops Whether the medicine reduces long-term complications Whether the safety profile remains acceptable over several years Factors That Affect Reta Peptide Results Factors That Affect Reta Peptide Results Individual outcomes may be influenced by: Starting body weight Presence of type 2 diabetes Age and general health Trial dose assignment Duration of treatment Tolerability and discontinuation Diet and physical activity Other medicines Adherence to the trial protocol People without type 2 diabetes have sometimes experienced greater average percentage weight loss than participants with diabetes in incretin-based weight-management trials