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And for the obesity nutrition researchers in the world, why would anyone do something this extreme if they didn't have to

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Since the sensitivity is usually neurological (starting at the nerve level) rather than dermatological (starting at the skin surface), topical lotions and numbing creams often provide limited relief

Nature 436 , 933938 (2005)

Germline deletion of PPAR is embryonically lethal 28,29 , but its overexpression in the adipose tissue improves lipid metabolism and leads to resistance to diet-induced obesity 30