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Several factors can cause this tiredness: Appetite suppression : Semaglutide can suppress appetite, reduce calorie intake, and cause a temporary drop in energy levels

Sources & Further Reading Clinical Trials & Research: STEP Trial Program (Semaglutide) New England Journal of Medicine SURMOUNT Trial Program (Tirzepatide) New England Journal of Medicine TRIUMPH-4 Trial (Retatrutide) Eli Lilly Phase 3 Results, December 2025 OASIS 4 Trial (Oral Semaglutide) Novo Nordisk, 2025 Orforglipron Phase 3 Trial Results Eli Lilly, 20252026 SELECT Trial (Cardiovascular Outcomes) NEJM, 2023 UAE-Specific Sources: Emirates Drug Establishment Foundayo Approval, April 2026 Gulf News "New daily weight-loss pill approved in UAE" Arabian Business "UAE approves Eli Lilly's orforglipron weight loss pill" Khaleej Times "Are Ozempic, Mounjaro covered by insurance in the UAE?" Dubai Population Health Survey Overweight/Obesity Prevalence Data Additional Sources: r/semaglutide, r/Mounjaro, r/Ozempic Reddit community discussion analysis Frequently Asked Questions Ozempic costs AED 744-1,200/month at pharmacies (or AED 1,800-2,200 in bundled clinic packages)

Devi R, Kaur N, Gupta AK

Hes also had a history of chronic lower gastrointestinal (GI) tract issues

The how and why of exocytic vesicles