It also explains retatrutide's unique side effect: dysesthesia (abnormal skin sensations) is seen only in retatrutide users, not tirzepatide or semaglutide users, and is likely related to glucagon receptor activation or its downstream metabolic effects
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However, researchers discovered something crucial: at the doses used in retatrutide, the GLP-1 and GIP components effectively manage glucose levels
Both medications are TGA approved for the treatment of heart failure with preserved ejection fraction (HFpEF), but at the time of writing, neither is PBS subsidised for this indication (refer to the PBS schedule and TGA website for full details)
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