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A 2019 meta-analysis found berberine supplementation resulted in average weight loss of 23 pounds over 12 weeks, considerably less than the 1522% weight loss observed with GLP-1 agonists in clinical trials
For a subcutaneous B12 injection, a finer, shorter needle is used: around 25 to 27 gauge and half to five-eighths of an inch
Consistency within a protocol cycle is important
Eligible participants were 18-70 years old, of any sex, with a disease duration of 5 years, a body mass index (BMI) of 24-40 kg/m, and glycated hemoglobin (HbA1c) between 6.5% and 9.0%
Hunger may be more noticeable, especially early on, but semaglutide and other GLP-1 medications can make this approach surprisingly doable
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