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The approval, which came 20 days before Takedas scheduled PDUFA date, makes Fruzaqla the first and only selective inhibitor of all three VEGF receptor kinases approved in the U.S

K50.0 Crohns Disease of Small Intestine K50.1 Crohns Disease of Large Intestine K50.8 Crohns Disease of Both Small and Large Intestine (Ileocolitis) K50.9 Crohns Disease, Unspecified Associated and Complication Codes For enteropathic arthropathy (M07.6x) , ICD-10-CM guidelines require sequencing the underlying IBD (K50.x) as the principal/first-listed diagnosis

Without controlled human studies, any dosing discussion is speculative and should be considered unsafe outside research settings

Ahn et al., 2019