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While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism

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J Burn Care 31(1):158175 Nyberg P, Xie L, Kalluri R (2005) Endogenous inhibitors of angiogenesis

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In vitro permeation studies show cumulative skin transport reaching 40.1 4.7 g/cm for coated liposomal VC vs 19.2 3.2 g/cm for conventional liposomes and ~9 g/cm for solution, demonstrating markedly higher deposition in deeper layers